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CTI BioPharma’s PRE-VENT Trial Misses Endpoint in Severe COVID

Pacritinib did not demonstrate a clinical benefit in treating the sickest patients with COVID-19 in PRE-VENT trial.

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By: Kristin Brooks

Managing Editor, Contract Pharma

CTI BioPharma Corp. announced topline results from the PRE-VENT trial (NCT04404361) of pacritinib in hospitalized patients with severe COVID-19. PRE-VENT, a randomized, double-blind, placebo-controlled multicenter study, compared pacritinib/standard of care versus placebo/standard of care in hospitalized patients with severe COVID-19, including patients with and without cancer. The primary endpoint of the trial was the proportion of patients who progressed to invasive mechanical ventilation and/...

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